Work

PDLIM3 expression is implicated in the invasive behavior of glioblastoma stem cells and their ability to form neurospheres.

Year: 2025

Type: article

Abstract: The recurrence of glioblastoma can be attributed to the high invasiveness and resistance of glioblastoma stem cells (GSCs). Therefore, it is crucial to investigate the molecular mechanisms that drive the agressiveness of these cells. This research focuses on the actin-associated protein PDLIM3 that we found overexpressed in GBM and in highly invasive GSCs. Suppressing PDLIM3 expression with targeted siRNAs significantly decreases cell invasion. Additionally, our findings highlight that PDLIM3 is essential for GSCs in forming neurospheres. This research provides the first evidence that PDLIM3 may contribute to the aggressiveness of glioblastoma by facilitating GSCs sphere formation and enhancing their invasiveness.

Source: PubMed

DOI: 10.17912/micropub.biology.001613

Authors: Yvan Nicaise, Caroline Delmas, Elisabeth Cohen-Jonathan-Moyal, Catherine Seva

Institutions: Centre de Recherches en Cancérologie de Toulouse, Institut universitaire du cancer de Toulouse Oncopole

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4412650367

FWCI:

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