Work

Electrochemical synthesis of aziridines, pyrrolidines and oxazolines enabled by azo-free alcohol amination

Year: 2025

Type: article

Abstract: We report a mild, economical electrochemical amination that expands Mitsunobu-like reactivity to weakly acidic nucleophiles via anodic oxidation, enabling access to aziridine, pyrrolidine, and oxazoline motifs from amino alcohol substrates.

Source: Chemical Science

DOI: 10.1039/d5sc03101j

Authors: Emma A. Hale, Qilei Zhu

Institution: University of Utah

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: University of Utah, American Chemical Society Petroleum Research Fund

Award: G2033076377