Work

Combining electroless ionisation mass spectrometry with solid-phase extraction for the direct analysis of beta-agonists in bovine urine

Year: 2025

Type: article

Abstract: A novel method combining electroless ionisation mass spectrometry (ELI-MS) with solid-phase extraction (SPE) cartridges enables direct analysis of beta-agonist residues in bovine urine (SPE-ELI-MS). Using a syringe plunger and a battery-powered DIY syringe pump mounted on an XYZ-linear stage, rapid sample clean-up and precise positioning were achieved. Optimisation of spray solvent and nozzle placement improved performance, yielding high sensitivity, repeatability, linearity, and trueness with internal standard correction. This approach offers a simple, efficient solution for analysing organic residues in biological samples, with strong potential for future on-site applications.

Source: Analytical and Bioanalytical Chemistry

DOI: 10.1007/s00216-025-06019-3

Authors: Sjors Rasker, Joris Schipperheijn, Stefan Kooij, Marco H. Blokland, Cees J. M. van Rijn, Ane Arrizabalaga-Larrañaga

Institutions: Wageningen University & Research, Van der Waals-Zeeman Institute, University of Amsterdam

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,990

OpenAlex ID: W4412652913