Work

Development of Histotripsy as a Local-Regional Liver Cancer Therapy: Preclinical to Clinical Translation

Year: 2025

Type: article

Abstract: Preclinical and clinical histotripsy studies demonstrating feasibility, safety, efficacy, and antitumor immunomodulatory effects support the clinical translation of histotripsy, making it a unique local-regional treatment option for primary and metastatic liver cancer.

Source: Radiology Imaging Cancer

DOI: 10.1148/rycan.240403

Authors: Tejaswi Worlikar, Nathan Loudon, Valerie M. Khaykin, Man Zhang, Clifford S. Cho, Timothy Hall, Eli Vlaisavljevich, J. Brian Fowlkes, Neehar D. Parikh, Zhen Xu, Mishal Mendiratta-Lala

Institutions: University of Michigan, Michigan Medicine, Michigan State University, Van Andel Institute, Virginia Tech

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Focused Ultrasound Foundation, National Institutes of Health, National Cancer Institute

Awards: G1536606743, Novel, Noninvasive, Rapid Tumor Ablation Technology using Histotripsy

OpenAlex ID: W4412654650

FWCI: 1.41

Cites: 72

Cited by: 6

Related to: 10