Garlic Extract Triggers Cytotoxicity, DNA Damage, and Cell Cycle Arrest in Human Leukemic Cells via Oxidative Stress.
Year: 2025
Type: article
Abstract: of 4.72 mg/mL. Tests for oxidative stress indicated significant increases (p<0.05) in the production of Malondialdehyde (MDA) and activity of glutathione peroxidase in GE-treated cells compared to the control group. Data obtained from the comet assay indicated that GE causes DNA damage in HL-60 cells in a concentration-dependent manner. GE treatment modulated cell cycle progression in HL-60 cells, leading to an arrest at the G2/M phase. In summary, our current investigation underscores that GE effectively curbs cell proliferation, induces DNA damage, and enforces cell cycle arrest of HL-60 cells, with these primary effects associated with oxidative stress. These findings contribute to a deeper understanding of the potential therapeutic role of GE in combating acute promyelocytic leukemia and other health challenges.
Source: PubMed
Language: English
Topic: Garlic and Onion Studies
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
Awards: RCN-UBE: HBCU Faculty Collaborative Network for the Integration of Artificial Intelligence and Machine Learning into Teaching General Biology, Distributed Learning for Undergraduate Programs in Data Science at Diverse Universities, G6471382802, RCMI Center for Health Disparities Research, G9000041901
OpenAlex ID: W4412655092