Association Between Hypertension with and Without Left Ventricular Hypertrophy and the Expression of a Panel of microRNAs in an Iranian Population
Year: 2025
Type: article
Study design: Observational Study
Abstract: Highlights: Left ventricular hypertrophy (LVH) is a critical independent predictor of cardiovascular mortality and is strongly associated with hypertension.Given the diagnostic potential of microRNAs (miRNAs) as biomarkers in hypertension, this study aimed to investigate their expression profiles.The findings underscore the significant involvement of miR-222 and miR-155 in hypertension and LVH pathogenesis. Introduction: Given the established role of microRNAs (miRNAs) in hypertension (HTN), this study aimed to analyze the expression of a defined miRNA panel in hypertensive individuals, both with and without left ventricular hypertrophy (LVH), compared with normotensive controls within an Iranian population. Methods: We conducted a cross-sectional study with case-control sampling, comprising three study groups: controls, HTN, and HTN+LVH. Through an extensive literature review, we selected a panel of eight miRNAs (miR-1, miR-21, miR-29a, miR-29b, miR-133, miR-155, miR-221, and miR-222) for analysis using real-time PCR. Gene expression data were analyzed through a general linear model implemented in R programming. Results: value among all models). Conclusions: HTN without LVH might be associated with the downregulation of miR-1 and miR-155 and the upregulation of miR-222. HTN, along with LVH, might be associated with the downregulation of miR-1 and miR-21 and the upregulation of miR-222. Increasing years of experiencing HTN were correlated with the upregulation of miR-155 and miR-222. The largest effect size was for miR-222.
Institution: Iran University of Medical Sciences
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412656091