Metal-free hypervalent iodine-mediated synthesis and biological evaluation of 2-[(3-aryl-isoxazol-5-yl)methoxy)]benzaldehydes
Year: 2025
Type: article
Abstract: A series of 2-[(3-aryl-isoxazol-5-yl)methoxy]benzaldehydes were synthesized through metal-free hypervalent iodine-mediated [3+2]-cycloaddition between 2-(2-propynyloxy)benzaldehyde and aldoximes.All new products were screened for their antibacterial activity against a number of gram-positive and -negative bacterial strains.Further, antifungal activity of these compounds was also evaluated against C. albicans.2-[(3-(3-Tolyl-isoxazol-5-yl)methoxy)]benzaldehyde and 2-[(3-(3-fluorophenyl-isoxazol-5-yl)methoxy)benzaldehyde were found to be the most potent amongst all the synthesized compounds.Antioxidant properties were also evaluated by using DPPH radical scavenger method in which 2-[(3-(3-bromophenylisoxazol-5yl)methoxy)benzaldehyde showed the highest antioxidant activity.All new products were also screened for their in vitro cytotoxicity against mouse fibroblast and plant cell germination cell lines.
Source: ARKIVOC
Authors: Bharti, Deepansh Sharma, Vishwas Chaudhri, Viktor V. Zhdankin, Ravi Kumar
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4412657779