Work

Metformin modifed UiO-66-NH2 as a super basic nanocatalyst for the four component synthesis of dihydropyridines

Year: 2025

Type: article

Abstract: This study presents the synthesis of a novel metal-organic framework (UiO-66-NH-nBut-Met) using PSM (post-synthetic modification) of UiO-66-NH 2 with metformin. The formation of UiO-66-NH-nBut-Met nanocatalyst was confirmed using analytical techniques, including BET, TEM, FT-IR, XRD, TGA, SEM, elemental mapping, and CHN analyses. Subsequently, the catalytic performance of the UiO-66-NH-nBut-Met was explored in the four-component synthesis of 1,4-dihydropyridines. The obtained results demonstrated remarkable productivity (excellent yields: 91–97%), within short reaction times (< 7 min) in solvent-free conditions. The enhancement of the catalytic activity of UiO-66-NH-nBut-Met compared to UiO-66-NH 2 can be attributed to metformin (N, N-dimethyl biguanidine) containing polydentate nitrogen donor ligands, as a super-basic agent. Furthermore, the catalyst demonstrated remarkable recyclability, maintaining high catalytic activity even after five consecutive runs.

Source: Scientific Reports

DOI: 10.1038/s41598-025-11840-y

Authors: Leila Ghasempour, Sakineh Asghari

Institution: University of Mazandaran

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

Funder: University of Mazandaran