Therapeutic effects of Lacticaseibacillus paracasei PC-H1 in alleviating colitis through restoring intestinal barrier and regulating gut microbiota
Year: 2025
Type: article
Abstract: Ulcerative colitis (UC), a subtype of inflammatory bowel disease (IBD), disrupts intestinal barrier integrity and microbial homeostasis. This study investigated the therapeutic potential of Lactobacillus paracasei PC-H1 in a murine UC model. L. paracasei PC-H1 administration significantly ameliorated colitis severity, as evidenced by restored body weight, colon length, and reduced disease activity index (DAI) scores and pro-inflammatory cytokine levels. Mechanistically, L. paracasei PC-H1 enhanced mucosal barrier function by upregulating tight junction proteins (ZO-1, occludin, claudin-3) and controlling colonic inflammation. Notably, high-dose inactive L. paracasei PC-H1 outperformed viable bacteria in reshaping gut microbiota composition and establishing a novel microbial homeostasis. These findings demonstrate that L. paracasei PC-H1 mitigates ulcerative colitis progression by protecting intestinal barrier integrity and restoring microbiota homeostasis.
Source: Journal of Functional Foods
Authors: Guoding Cao, Hanyue Zhu, Shuang Liang, Wanyu Cao, Ran Liu, Xinhang Li, Yichen Jiang, Yong Fang
Institutions: Harbin Medical University, Qilu Medical University
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,800
Awards: G3795304070, G8722408578
OpenAlex ID: W4412657895