Differentiation-associated ISG expression of NK cells in chronic viral infection
Year: 2025
Type: article
Abstract: that correlated with NK cell differentiation state. These genes are governed by fate-determining transcription factors, including ETS1, FLI1, and Eomes, and appear to be constitutively expressed rather than driven by persistent IFN exposure. Network analysis suggested that NK cell ISGs participate not only in antiviral defense but also in processes such as transport and metabolism, underscoring their role in shaping NK responses during health and chronic viral infection.
Source: iScience
Authors: Franziska Keller, Robert Lorenz Chua, Timo Trefzer, Katharina Jechow, Liane Bauersfeld, Fabian Beier, Sagar, Özlem Sogukpinar, Giuseppe Rusignuolo, Marta Rizzi, Roland Eils, Andreas Pichlmair, Marco Binder, Bertram Bengsch, Christoph Neumann-Haefelin, Volker Lohmann, Tobias Boettler, Christian Conrad, Robert Thimme, Maike Hofmann
Institutions: University of Freiburg, University Medical Center Freiburg, Humboldt-Universität zu Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charité - Universitätsmedizin Berlin, German Center for Infection Research, Technical University of Munich, German Cancer Research Center, Heidelberg University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funder: Deutsche Forschungsgemeinschaft
OpenAlex ID: W4412658391