Work

An analysis of preterm birth rates among 500 kindreds with epidermal differentiation disorders

Year: 2025

Type: article

Abstract: Epidermal differentiation disorders (EDDs) are a group of genetic skin diseases frequently associated with preterm birth, although this connection has not been comprehensively evaluated across all known genotypes. In this study, we analysed 567 kindreds from the National Registry for Ichthyosis to assess preterm birth rates across 54 genetic causes of EDDs. Our findings suggest genotype-specific risks for preterm birth, possibly mediated by biological pathways including arachidonic acid metabolism and steroid sulfatase activity.

Source: British Journal of Dermatology

DOI: 10.1093/bjd/ljaf308

Authors: Caroline Echeandia-Francis, Keith A Choate

Institution: Yale University

Language: English

Topic: Skin and Cellular Biology Research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Yale University, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Yale Liver Center