Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: This study aimed to investigate the correlation between interleukin-5 (IL-5) and interleukin-17 (IL-17) with specific aeroallergens in pediatric asthmatic patients. Patients and Methods: A cross-sectional study included (100) pediatric asthmatic patients, focusing on demographics, Biomarkers, and aeroallergens. Results: The results showed that eosinophilic asthma patients had considerably higher levels of IL-5 (p=0.0015), especially those who were sensitized to allergens like sorrel, white ash, and sweet vernal mix. IL-17 levels were associated with sensitivity to firebush and CCD indicators and were higher in neutrophilic asthma (p=0.0072). Overlapping biomarker elevations in mixed granulocytic asthma suggested intricate inflammatory processes. Conclusion: The significance of IL-5 and IL-17 as biomarkers for asthma phenotype in juvenile patients is highlighted by this study. IL-5 plays a crucial role in allergen-induced asthma, as seen by the strong association it has with particular allergens. Asthma treatment could be completely transformed by personalized therapy based on biomarker analysis.
Authors: Khalid J. Salem, Alaa S. Alattabi, Dhamiaa M. Hamza, Haidar A. N. Abood
Institutions: Mustansiriyah University, University of Kerbala
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412659584