Isolation and Identification of Diterpenoids from Euphorbia helioscopia and Their Anti-inflammatory Activities
Year: 2025
Type: article
Abstract: Phytochemical investigation of 70% ethanol extract of Euphorbia helioscopia led to eight diterpenoids, including four jatrophane-type (1–4), three abietane-type (5–7) and one lathyrane-type (8). Among them, (5E,11E)-3β-benzoyloxy-7β,14α,15β-trihydroxyjatropha-9-one (1) was a new jatrophane diterpenoid. An extensive array of spectral analyses, including HR-ESI-MS, IR, UV, 1D and 2D NMR, as well as quantum chemical calculations of ECD curve, were utilized for their structural elucidation. Bioassay results showed that compounds 2–3 and 6–8 could significantly inhibit NO release on LPS-induced RAW 264.7 cells, especially for jatrophane diterpenoid 3 and abietane diterpenoid 8 that showed stronger activities with the IC50 values of 9.16 ± 0.70 and 5.74 ± 0.27 μM.
Source: Records of Natural Products
Authors: Liping Dai, Jinke Zheng, Jun Chi, Bin Cao, Huili Li
Institution: Henan University of Traditional Chinese Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412663063