Generation of APOE ε3/ε4 and APP-mutant human pluripotent stem cell line derived from an Alzheimer’s patient
Year: 2025
Type: article
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with mutations in the amyloid precursor protein (APP) gene and the apolipoprotein E (APOE) gene identified as significant risk factors. Here, we generated induced pluripotent stem cells (iPSCs) from an Alzheimer's patient carrying heterozygous mutations in APOE (ε3/ε4) and APP. The derived iPSCs exhibited a normal karyotype, expressed pluripotency markers, and demonstrated the capacity to differentiate into the three germ layers.
Source: Stem Cell Research
Authors: Yingtong Zhai, Jingke Cheng, Xiangge Guo, Xumeng Wang, Min Ma, Shan Wang, Qian Ren
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,360
Awards: G1117312990, G1381461759, G7696193182
OpenAlex ID: W4412664686