Work

Correlation of Coronary Heart Disease Mortality with HALP Score: A Cross-Sectional Study Based on NHANES

Year: 2025

Type: article

Abstract: This study investigates the association between HALP score (hemoglobin, albumin, lymphocytes, platelets) and all-cause mortality in coronary heart disease (CHD) patients using NHANES data (1998-2018). Eligible CHD patients were grouped into Q1-Q4 by HALP quartiles. Analyses included weighted Cox models, restricted cubic spline (RCS) regression, Kaplan-Meier (K-M) curves, and subgroup analyses. Results showed 937 all-cause deaths. After covariate adjustment, Q2-Q4 had lower mortality risk (HR=0.74, 0.68, 0.70; 95% CIs respectively). A significant J-shaped nonlinear relationship was found (nonlinear P<0.001) with a turning point at 78.02: each 1-unit increase in HALP ≤78.02 reduced death risk by 1.3% (HR=0.987), while the protective effect plateaued above this. K-M curves showed higher HALP correlated with higher survival, and subgroup analyses confirmed robustness. The HALP score exhibits a J-shaped relationship with all-cause mortality in patients with coronary heart disease (CHD) and has potential prognostic value.

Source: Social Medicine and Health Management

DOI: 10.23977/socmhm.2025.060117

Authors: Ji Ouyang, Mengjiao Li, Jiayuan Song, Zhixi Hu

Institutions: Hunan University of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Changchun University of Chinese Medicine

Language: English

Topic: Inflammatory Biomarkers in Disease Prognosis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Natural Science Foundation of China