Year: 2025
Type: preprint
Abstract: Intratumour microbiome can restore anti-tumour immunity with bacterial peptides potentially serving as neoantigens, while robust in-silico tools for bacterial neoantigen identification remain lacking. We developed bac terial neo antigen ( bacNeo ), a multi-omics based computational toolkit that contains three modules to classify bacterial taxonomy, identify host HLA alleles, and predict bacterial neoantigens. bacNeo could enable personalised neoantigen discovery to advance therapeutic strategies across diverse cancer types.
Authors: Yunzhe Wang, Li Yuan, Katie W. Gu, Xiangdong Cheng, Bo Wen, Zhao Zhang
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G2586681493, G7726319842
OpenAlex ID: W4412676958