侏儒蛤（Mulinia lateralis）的表观遗传调控与母源-合子转换：来自染色质状态图谱与转录组学的洞见
Year: 2025
Type: article
Abstract: Bivalve mollusks are a major and economically important group within the phylum Mollusca. However, research on the fundamental biology of their embryonic development remains limited. The dwarf surf clam Mulinia lateralis has recently gained recognition as an ideal model for bivalve embryological studies due to its short life cycle and high reproductive capacity. In this study, we explored the epigenetic mechanisms driving embryogenesis in M. lateralis by analyzing chromatin states and transcriptomic data, with a particular focus on the maternal-to-zygotic transition (MZT). For the first time in M. lateralis, we successfully applied the CUT&Tag technique to generate high-resolution profiles of H3K4me1, H3K4me3, H3K27me3, and H3K27ac at key developmental stages. Our findings revealed extensive histone modification reprogramming, underscoring dynamic chromatin changes occurring during early embryonic development. By integrating chromatin profiling with transcriptomic analysis, we identified the timing of the MZT in M. lateralis, pinpointing its occurrence between the morula and gastrula stages, and uncovered candidate genes essential for embryogenesis. This study enhances our understanding of epigenetic regulation in bivalve embryogenesis and provides a novel methodological framework for marine invertebrate research. By establishing M. lateralis as a valuable model, our work not only contributes to the refinement of bivalve aquaculture strategies but also lays the foundation for future functional studies of developmental genes and comparative analyses across bivalve species.
Source: 动物学研究
Authors: Shi Jia-Le, 中国海洋大学海洋生命学院教育部海洋遗传育种重点实验室, 山东 青岛 266003, 中国, Liu Jia-Xiang, Wei Zhong-Cheng, Yin Miao-Miao, Yang Zu-Jing, Hu Jing-Jie, Ye Zhi, Bao Zhen-Min, 中国海洋大学三亚海洋研究院海南省热带水生种质资源重点实验室, 海南 三亚 572024, 中国
Institution: Ocean University of China
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412682932