Work

Downregulation of Cyclin-D, Wnt3a, and C-Myc in prostate cancer by dose-dependent combination of concentrated marine minerals and curcumin

Year: 2025

Type: article

Abstract: Prostate cancer presents a significant global health challenge, often exhibiting resistance to chemotherapy drugs and causing severe side effects from conventional treatments.These side effects include toxicity to normal cells and mineral deficiencies, which can lead to complications such as acute diarrhea, electrolyte imbalances, and chemotherapyinduced peripheral neuropathy.Natural compounds like curcumin offer promising synergistic anticancer properties with relatively low toxicity and can reduce co-delivered drug resistance.Concurrently, concentrated marine mineral (CMM) solutions, rich in essential minerals, are being explored as adjunct therapies to mitigate chemotherapyinduced mineral deficiencies and potentially enhance curcumin's efficacy and uptake.This study evaluates the comparative cytotoxic effects of curcumin, CMM, and their combination against DU145 prostate cancer cells and HEK293 normal kidney cells, using cisplatin as a benchmark.Curcumin and CMM demonstrate potent inhibition of DU145 cells, classifying them as highly active while showing reduced cytotoxicity towards HEK293 cells compared to cisplatin.Combining curcumin and CMM enhances cytotoxicity against prostate cancer cells while mitigating toxicity to normal cells.Moreover, the combined treatment effectively downregulates Cyclin-D1, Wnt3a, and C-Myc expression in prostate cancer cells, with optimal effects observed at a 5 ppm curcumin and 5 ppm CMM ratio.These results underscore the potential of curcumin and CMM as a synergistic therapeutic strategy for prostate cancer, offering enhanced efficacy and reduced side effects compared to conventional cisplatin chemotherapy.

Source: Journal of Applied Pharmaceutical Science

DOI: 10.7324/japs.2025.217025

Authors: Syafika Alaydrus, Sriwidodo Sriwidodo, Ajeng Diantini, Riezki Amalia, Wahyuni Wahyuni, Ayu Wulandari

Institutions: Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu, Padjadjaran University, Universitas Halu Oleo

Language: English

Topic: Curcumin's Biomedical Applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412690289