Radiopaque poly(5-acrylamido-2,4,6-triiodoisophthalic acid)-based copolymers as theranostic carriers for image-guided drug delivery
Year: 2025
Type: article
Abstract: -isopropylacrylamide) (PNIPAM) and poly(5-acrylamido-2,4,6-triiodoisophthalic acid) (PAATIPA), designed to combine radiopacity with drug delivery capabilities. PAATIPA's high iodine content provides strong contrast in CT scans, while PNIPAM's thermoresponsiveness allows for self-assembly at higher temperatures. The anionic nature of PAATIPA allows the efficient encapsulation of the cationic small-molecule rhodamine 6G. The copolymers exhibited an enhanced encapsulation of cationic rhodamine 6G (>90% at 35 w/w% of rhodamine) and excellent biocompatibility, as demonstrated in cytotoxicity assays. This study emphasizes the potential of PAATIPA-based copolymer materials as multifunctional, radio-opaque and stimuli-responsive materials for theranostic applications.
Source: Nanoscale
DOI: 10.1039/d5nr02033f
Authors: Kristyna Kolouchova, Nele Pien, Fatma Nalan Cetin, Zulfiya Cernochova, Joeri Van Meerssche, Miroslav Slouf, Andrei-Alexandru-Antonio Bara, Ondrej Groborz, Martin Hruby, Sandra Van Vlierberghe
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: hybrid
Awards: Smart Solutions for Cancer Care: Advancing Treatment with Theranostic Polysaccharides, G2920949263, Thermoresponsive poly[N-(2,2-difluorethylacrylamide)] 19F MRI tracer-based materials as potential multipurpose theranostics, G3810236772, G4396925471, 3D-bioprinting of Ion Conducting Gelatin Hydrogels for Skeletal Muscle Tissue Engineering, G5449815361, Exploiting polymersomes to create 'smart' wound dressings with diagnostic and antimicrobial capabilities, Targeting tendon-bone junction regeneration: development of a gradient scaffold., Novel Radiosensitizers for FLASH-RT Therapy, G8181324682, Infection-triggered smart dermal matrix for wound healing purposes, G883562873
OpenAlex ID: W4412692496