Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Two hydrogen sulfide photoreleasing molecules (photo-HSRMs), 3-hydroxy-2-naphthalene-methanethiol and the corresponding disulfide, have been synthesized, and their properties and photochemical reactivity have been explored. Both compounds are stable in the neat form and in aqueous solutions in the dark but release H 2 S under exposure to UVA and UVB light in good quantum and chemical yields. In the presence of thiols, such as cysteine, glutathione, and mercaptoethanol, the yield of hydrogen sulfide release reaches 90%. The mechanism of H 2 S photorelease from these photo-HSRMs is discussed.
Source: The Journal of Organic Chemistry
Authors: Kun Wang, Vladimir Popik
Institution: University of Georgia
Language: English
Topic: Sulfur Compounds in Biology
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funder: Division of Chemistry
Award: G5894797328
OpenAlex ID: W4414354507