Work

QD–Aptamer Biocomplexes with Specificity to the Epidermal Growth Factor Receptor

Year: 2025

Type: article

Abstract: Complexes based on quantum dots (QDs) and aptamers can combine the luminescence properties of nanoparticles and the specificity of interaction of an aptamer with a target. In this work, a method for obtaining the complexes of QDs of various types (CdSe/ZnS and InP/ZnS) with DNA aptamers Gol1 and U8 was proposed. These aptamers determine the specificity of interaction with the epidermal growth factor receptor (EGFR). The complexes obtained have great potential in the field of optical visualization and diagnostics of oncological diseases.

Source: INEOS OPEN

DOI: 10.32931/io2554a

Authors: M. V. Grigoreva, O. A. Otmakhova, O. N. Karpov

Institutions: Russian Academy of Sciences, A.V. Topchiev Institute of Petrochemical Synthesis

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Russian Science Foundation