Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: This study aimed to analyze survival and risk factors for death in children with neuroblastoma that may contribute to a viable risk classification for low-income countries. METHODS: A historic cohort involving patients under 19 years of age with neuroblastoma was followed at a reference center in Northeast Brazil between July 2005 and July 2020. Data on sociodemographic, were collected. The outcomes studied were recurrence, disease progression, and five-year mortality. Multivariate analysis of Cox proportional hazards for death was performed. Overall and eventfree survivals were evaluated using the Kaplan-Meier method and the comparison between the groups studied, by the log-rank test. RESULTS: Patients (n=126) were predominantly female with a median age of 26.5 months. Most presented primary adrenal, tumor stage 4 according to the International Neuroblastoma Staging System, unfavorable histology, and median serum lactate dehydrogenase (LDH) levels of 640.5 U/L. LDH≥640.5 U/L (hazard ratio [HRa] 2.49; 95% confidence interval [CI] 1.57-3.95; p<0.001) and stage 4 (HRa 1.67; 95%CI 1.00-2.78; p=0.047) were identified as risk factors for death. The overall survival was 32.4%, showing distinct curves regarding LDH serum levels and staging (log-rank p<0.05); the event-free survival was 26.3%. CONCLUSIONS: Elevated LDH serum levels were a risk factor for five-year mortality, and can be utilized as a prognostic marker in resource-limited settings.
Source: Revista Paulista de Pediatria
Authors: Roberta Gomes Ribeiro Gonçalves Pinto, Mecneide Mendes Lins, Kaline Maria Maciel de Oliveira Pereira, Ticiana Ester Mattos Pascoal Meira, Eduarda Coutinho Albuquerque Neiva Coêlho, Alice Rodrigues Barbosa de Moraes, Marina Lundgren de Melo Batista, Leticia Ribeiro Maciel Pereira, Maria Júlia Gonçalves de Mello
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412700114