CHEMICAL AND BIOLOGICAL INVESTIGATION OF Cattleya nobilior Rchb. F. (Orchidaceae): TARGETING ON PHENANTHRENE AND STILBENOID DERIVATIVES
Year: 2025
Type: article
Abstract: Orchidaceae family is a valuable source of bioactive compounds, particularly phenanthrenes and stilbenoids, which exhibit promising pharmacological properties. Cattleya nobilior Rchb. F. remains chemically and biologically unexplored, yet its potential bioactivity warrants investigation. This study aimed to identify phenanthrenes and stilbenoids from C. nobilior and evaluate their anti-Trypanosoma cruzi and cytotoxic activities. Extracts from leaves, pseudobulbs, roots, and rhizomes were obtained using sequential solvent extraction by accelerated solvent extraction. Their biological effects were assessed against T. cruzi epimastigotes and cancer cell lines (Kasumi-1, CCRF-CEM, HCT-116, and MCF-7). Metabolomic profiling (liquid chromatography-diode array detection-mass spectrometry (LC-DAD-MS)) and multivariate analyses correlated chemical composition with bioactivity. Rhizome extracts (CnRz-DM5, CnRz-DM50) inhibited HCT-116 cells (> 80%), while CnBb-DM5, CnRz-DM5, and CnRo-DM5 inhibited > 90% of leukemic cells. CnRo-DM5 also exhibited moderate anti-T. cruzi activity (half-maximal inhibitory concentration (IC50) = 33.3 µg mL–1). Metabolomic analysis suggested 67 phenanthrenes and stilbenoids associated with cytotoxicity. Guided by these findings, the most active extract was fractionated, leading to the isolation of gigantol and batatasin III. This study provides the first chemical and biological insights into C. nobilior, reinforcing its potential as a source of bioactive phenanthrenes and stilbenoids with anticancer and antiparasitic properties.
Source: Química Nova
Authors: Caroline de Moura Costa, Katyuce Souza Farias, Izadora Bonfim, Heron F. V. Torquato, Samara Requena Nocchi, Laís Azevedo Rodrigues, Júlio Mentha Almeida, Flávio Macedo Alves, Alda Maria Teixeira Ferreira, Helori Vanni Domingos, Edgar J. Paredes-Gamero, Leticia V. Costa-Lotufo, Carlos Alexandre Carollo, Denise Brentan Silva
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $330
OpenAlex ID: W4412723562