Work

Recent advances in the synthesis of fluorinated heterocycles and a review of recent FDA-approved fluorinated drugs

Year: 2025

Type: review

Abstract: value in favor of drugs. Now, the belief in fluorinated compounds has become so strong that the judicious incorporation of fluorine into organic compounds has become one of the important tools for improving the chances of getting better therapeutically effective compounds. The fusion of the above two individually dominating fields-heterocyclic framework and fluorine atom-in the potential drug compounds offers an even greater likelihood of discovering therapeutically useful agents. This is one of the main reasons why a significant number of fluorinated heterocyclic drugs are being approved by the FDA each year. Although fluorinated compounds have many benefits, the introduction of fluorine substituents remains challenging; particularly, the introduction of fluorine atoms into heterocyclic frameworks can increase the complexity of synthesis. Over the last few decades, several methods have been developed to introduce fluorine into organic compounds; however, fluorination of heterocyclic compounds remains an elusive task, although it is gradually being addressed. In this review, we present the most recent developments in the fluorination of heterocyclic compounds and discuss the chemistry of fluorinated heterocyclic compounds approved in the last and current years.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob00997a

Authors: Sayan Mukherjee, Ujala Rani, Girish Chandra, Shantanu Pal

Institutions: Indian Institute of Technology Bhubaneswar, Central University of South Bihar

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Department of Science and Technology, Ministry of Science and Technology, India