Year: 2025
Type: article
Abstract: DNA nanotechnology enables the precise construction of intricate nanoscale structures. Over the past two decades, significant progress has been made in incorporating dynamic functionalities into these nanostructures. Concurrently, innovative strategies have emerged for their self-assembly and surface patterning into larger, more complex architectures. This review explores the convergence of these two key capabilities-reconfigurability and hierarchical assembly-to engineer DNA origami superstructures with intrinsic dynamic behavior. We begin by outlining foundational strategies in dynamic design, hierarchical assembly, and surface placement, then review recent progress in leveraging these strategies to construct dynamic superstructures with emergent behaviors. The article concludes with a roadmap of major challenges and opportunities shaping the future of this rapidly evolving field.
Source: Nanoscale Horizons
DOI: 10.1039/d5nh00436e
Authors: Daniel Duke, Sierra Sterling, Teng Teng, Anna Altunina, Irina V. Martynenko, Yonggang Ke, Carlos E. Castro, Gaurav Arya
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4412756382