Work

Novel tryptophan 2,3-dioxygenase-targeted ruthenium( ii )-indole complex activates immunotherapy in vitro and in vivo

Year: 2025

Type: article

Abstract: mitochondrial damage, triggering a strong immune response. The tumor vaccine experiment revealed that In-Ru significantly reduced TDO levels and triggered ICD effect in liver cancer animal models. By reversing the immunosuppressive microenvironment, In-Ru facilitated the maturation of dendritic cells (DCs) and promoted T-cell infiltration, thereby achieving robust anti-tumor efficacy and long-lasting immune protection. This study represents the first report of a metal-arene complex with dual functions of TDO inhibition and ICD induction. It not only enhances anti-tumor immunogenicity but also effectively mitigates the risk of immune overactivation, offering a precise regulatory paradigm for the development of metal-based complexes in tumor immunotherapy.

Source: Chemical Science

DOI: 10.1039/d5sc03778f