Work

Evaluating caplacizumab's potential to mitigate thrombosis risk in aortic valve stenosis: a microfluidic and computational approach

Year: 2025

Type: article

Abstract: ) and effectively mitigated shear gradient-dependent platelet aggregation across all stenotic conditions. These findings highlight caplacizumab's therapeutic potential for thrombosis prevention in patients with aortic valve stenosis, offering a foundation for personalized antithrombotic approaches that could potentially reduce thrombotic complications associated with the disease.

Source: Lab on a Chip

DOI: 10.1039/d5lc00361j

Authors: Saeedreza Zeibi Shirejini, Mehrdad Khamooshi, Damien Riska, Martin Nikolov, Marjan Azimi, Shiyen L. Perera, Josie Carberry, Karen Alt, Shaun D. Gregory, Christoph E. Hagemeyer

Institutions: Monash University, Queensland University of Technology

Language: English

Topic: Blood properties and coagulation

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Heart Foundation of Australia, Monash University, National Health and Medical Research Council

Awards: A multidisciplinary approach to reducing complications with extracorporeal membrane oxygenation, A suture-less cannula for rapid, off-bypass implantation of left ventricular assist devices, Smart targeted nanoparticles for diagnosis and therapy, Reducing complications with artificial heart-lung machines

OpenAlex ID: W4412761720

FWCI: 2.953

Cites: 43

Cited by: 5

Related to: 10