Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea
Year: 2025
Type: article
Abstract: PURPOSE: Severe asthma with fungal sensitization (SAFS) is associated with life-threatening exacerbation and severe airflow limitation. We aimed to investigate the prevalence of fungal sensitization in asthma and clinical characteristics of SAFS. METHODS: This study analyzed data from the Cohort for Reality and Evolution of Adult Asthma in Korea and the Korean Severe Asthma Registry cohorts. Study subjects were classified based on fungal sensitization and asthma severity. Clinical characteristics of patients with severe asthma were compared according to fungal sensitization status. RESULTS: = 0.116) than those with SANFS. Multivariate analysis revealed that early diagnosed asthma was significantly associated with SAFS. CONCLUSIONS: The prevalence of fungal sensitization in severe asthma is approximately twice as high as in non-severe asthma. Early diagnosed asthma may be a risk factor for SAFS, and patients with SAFS face a greater burden of additional treatment compared to those with SANFS. SAFS has a distinct airway inflammation profile that differentiates it from SANFS.
Authors: Hyo-In Rhyou, Tae-Bum Kim, Sun-Young Yoon, Jae-Woo Kwon, Hye-Kyung Park, Sung-Ryeol Kim, Young-Hee Nam, Joo-Hee Kim, Young-Joo Cho, Ho Joo Yoon, Yoo Seob Shin, Jae-Woo Jung, Taehoon Lee, Yoon-Seok Chang, Sang-Heon Cho, Seung-Eun Lee, Byung-Jae Lee, Hwa Young Lee, Hyun Jung Jin, So-Young Park, Kyoung-Hee Sohn, Byung Keun Kim, Youngsoo Lee, Woo-Jung Song, Sang-Heon Kim, Chan Sun Park
Institutions: Inje University, Inje University Haeundae Paik Hospital, Asan Medical Center, University of Ulsan, Chungnam National University, Chungnam National University Sejong Hospital, Kangwon National University, Kangwon National University Hospital, Pusan National University Hospital, Pusan National University, Yonsei University, Hanyang University Seoul Hospital, Yonsei University Health System, Yongin Severance Hospital, Hanyang University, Dong-A University, Hallym University, Hallym University Medical Center, Ewha Womans University, Ewha Womans University Medical Center, Ewha Womans University Seoul Hospital, Ajou University, Chung-Ang University Hospital, Chung-Ang University Healthcare System, Chung-Ang University, Ulsan University Hospital, Seoul National University Bundang Hospital, Seoul National University, Seoul National University Hospital, Pusan National University Yangsan Hospital, Samsung Medical Center, Sungkyunkwan University, The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea, Yeungnam University Medical Center, Yeungnam University College, Yeungnam University, Chung-Ang University Gwangmyeong Hospital, Kyung Hee University, Korea University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G2356689393, G3275973520, G405460701
OpenAlex ID: W4412766018