Work

La-related protein 1 drives malignant progression and epithelial-mesenchymal transition in anaplastic thyroid carcinoma

Year: 2025

Type: article

Abstract: Anaplastic thyroid cancer (ATC) is an extremely aggressive and lethal malignancy characterized by a very short average survival time following diagnosis. Understanding the molecular mechanisms that drive this aggressiveness is vital for developing effective therapies. This study aimed to elucidate the role and function of La-related protein 1 (LARP1) in ATC progression. We quantitatively analyzed LARP1 expression in patient samples and ATC cell lines. Functional assays were performed to investigate LARP1's involvement in cancer-related processes, including inhibition of apoptosis, promotion of cell cycle progression, proliferation, colony formation, migration, and invasion. Our results revealed significantly elevated LARP1 expression in ATC tissues, which may be associated with poor patient prognosis. Experimental data demonstrated that LARP1 enhances oncogenic activities, promoting proliferative and invasive behaviors. These findings provide compelling evidence that LARP1 plays a crucial role in ATC malignancy, offering insights into pathophysiology and potential therapeutic targets.

Source: American Journal of Cancer Research

DOI: 10.62347/gupu2399

Author: Changtian Yin

Institutions: Zhejiang Provincial People's Hospital, Hangzhou Medical College

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Department of Education of Zhejiang Province, Natural Science Foundation of Zhejiang Province