Factors affecting chemotherapy-induced nausea and vomiting in patients with lung squamous cell carcinoma
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To identify factors associated with the severity of chemotherapy-induced nausea and vomiting (CINV) in patients with lung squamous cell carcinoma.Methods: A retrospective analysis was conducted on 301 LSCC patients who received chemotherapy between January 2021 and December 2024.CINV severity was assessed using the Index of Nausea, Vomiting, and Retching.Post-chemotherapy assessments included blood measurements, inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and serum albumin levels.Multivariate logistic regression was performed to identify factors associated with CINV severity.Results: A history of coronary heart disease significantly increased the risk of moderate to severe CINV (P = 0.010).Higher forced expiratory volume in one second (FEV 1 ) was associated with a reduced risk of severe CINV (P = 0.053).Higher albumin levels were associated with more severe CINV (P = 0.048).Elevated IL-6 levels were found to have a protective effect against severe CINV (P < 0.001).Higher partial pressure of oxygen (PaO 2 ) significantly reduced the risk of severe CINV (P = 0.002), while increased partial pressure of carbon dioxide (PaCO 2 ) was associated with greater CINV severity (P = 0.017).Conclusion: CINV severity in LSCC patients is influenced by a combination of pulmonary function (FEV 1 , PaO 2 , PaCO 2 ), inflammatory markers (IL-6, CRP, TNF-α), serum albumin levels, and cardiovascular comorbidities.These findings provide a foundation for personalized supportive care to enhance the quality of life in patients receiving chemotherapy.
DOI: 10.62347/fzaj6796
Author: Jia Wang
Institutions: Sichuan University, West China Hospital of Sichuan University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4412775504