Work

Lewis acid-promoted intramolecular cyclization of ortho -prenylated chalcones: application to first total synthesis of (±) involucrasin C and its novel analogues

Year: 2025

Type: article

Abstract: with slightly diminished yield provides a cheaper alternative. To assess diastereoselectivity, the prenyl group was replaced with a cinnamyl moiety, forming a third consecutive chiral center as a single diastereomer. Additionally, total synthesis of (±) involucrasin C, along with the synthesis of several structurally related novel analogues, is presented in this work.

Source: RSC Advances

DOI: 10.1039/d5ra04830c

Authors: Jarish Ahamad, Rashmi Ranjan Khatua, Faiz Ahmed Khan

Institution: Indian Institute of Technology Hyderabad

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: Council of Scientific and Industrial Research, India, Ministry of Education, India, Science and Engineering Research Board