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Influence of Polymorphisms in Gene SATB2 on Antipsychotics Response in Chinese Han Population.

Year: 2025

Type: article

Abstract: Background: Responses to antipsychotic drugs vary significantly among patients with schizophrenia. This study explored the correlation between rs1900327, rs7557687, rs733156, and rs6745135 in gene SATB2 and antipsychotics response in the Chinese Han population. Methods: This study included 228 patients with schizophrenia. The polymorphisms of SATB2 gene (rs1900327, rs7557687, rs733156, and rs6745135) in patients were measured using the KASP technique. During the study, patients received a single antipsychotic medication for a duration of eight weeks. The clinical efficacy was evaluated using the Positive and Negative Syndrome Scale (PANSS) scores. A patient with a decrease of at least 50% in the total PANSS score was categorized as a good responder, whereas those who did not meet this threshold were classified as poor responders. Results: > 0.05). Conclusion: The SATB2 gene polymorphisms were related to the effectiveness of antipsychotics in treating general psychopathological symptoms.

Source: PubMed

DOI: 10.2147/ndt.s511374

Authors: Xinzhe Du, Yukun Wang, Qian Zhang, Yao Gao, Xiao Wang, Wentao Zhao, Xiaodong Hu, Yu Zhang, Yong Xu, Bo Chen, Jihui Zhang, Sha Liu, Xinrong Li

Institutions: Shanxi Medical University, First Hospital of Shanxi Medical University, China National Pharmaceutical Group Corporation (China)

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4412785073

FWCI:

Cites: 35

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Related to: 10