Cobalt–nickel metal–organic frameworks (CNMs) as drug delivery agents for triple-negative breast cancer
Year: 2025
Type: article
Abstract: chorioallantoic membrane (CAM) assay demonstrated that the MD-CNM significantly inhibited tumor angiogenesis by downregulating key pro-angiogenic factors, including vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2), and angiopoietin 1 (ANG1) within the tumor microenvironment. These findings underscore the potential of CNMs as an innovative and efficient multidrug delivery platform for targeted cancer therapy, particularly for treating TNBC, offering a promising alternative to conventional chemotherapy with improved efficacy and reduced toxicity.
Source: Nanoscale Advances
DOI: 10.1039/d5na00193e
Institution: Indian Institute of Technology Madras
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,962
Awards: G2160311921, G3107647740, G4961854348
OpenAlex ID: W4412785437