Work

Discovery of the first-in-class Aurora B kinase selective degrader

Year: 2025

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2025.118006

Authors: Xiaoping Hu, Kevin Graciano, Jianping Hu, Chang Liu, Jiuyi Zhang, Ling Xie, Xian Chen, Yan Xiong, Jian Jin, Jia Xu

Institutions: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, University of Alabama at Birmingham, O'Neal Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Celgene, Icahn School of Medicine at Mount Sinai, Breast Cancer Research Foundation of Alabama, National Institutes of Health, School of Medicine, University of Alabama at Birmingham

Awards: An AVANCE NEO 600 MHz NMR Spectrometer System for Structural and Chemical Biology, G6181544450, An AVANCE NEO 400 MHz NMR Spectrometer for Chemical Biology and Drug Discovery, G8943699930

OpenAlex ID: W4412785880

FWCI: 0.255

Cites: 60

Cited by: 1

Related to: 10