Work

Prognostic Significance of Biomarkers of Inflammation and Myocardial Fibrosis in Assessing Response to Cardiac Resynchronization Therapy

Year: 2025

Type: article

Abstract: A significant proportion of patients undergoing cardiac resynchronization therapy (CRT) fail to respond despite standard selection criteria. This review examines the prognostic value of biomarkers related to myocardial stress (NT-proBNP), fibrosis (galectin-3, sST2), and inflammation (hsCRP, TNF-α, IL-6) in predicting CRT outcomes. NT-proBNP remains the most reliable marker, with reductions post-CRT indicating favorable response. Elevated levels of sST2 and galectin-3 are linked to adverse events and non-response. Integrating these biomarkers into clinical scoring systems may enhance patient stratification, though variability and lack of standardization remain challenges.

Source: Journal of Heart Disease and Therapy

DOI: 10.71295/jhdt.2025.020105

Authors: Aziza Khalikova, Timur Atanazarovich, Igor Tsoy, Bekzod Rozibaev

Institution: Tashkent Medical Academy

Language: English

Topic: Cardiac pacing and defibrillation studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4412806256

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