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A case of toxic encephaloneuropathy during treatment with nimorazole

Year: 2025

Type: article

Abstract: 5-nitroimidazoles (5-NI) are pharmacologically diverse drugs used mainly for anaerobic and parasitic infections. Metronidazole is the most widely used 5-NI and has rare neurotoxic effects, including cerebellar and brainstem dysfunction, encephalopathy, and seizures. Other (5-NI) have been studied as hypoxic cell radiosensitizers but are limited by dose-dependent side effects. Nimorazole is in use in Denmark for head-and-neck cancer and is considered safe. No cases of nimorazole-induced neurotoxicity like Metronidazole encephalopathy have been published. In this case, we report a patient who developed toxic encephaloneuropathy during nimorazole radiosensitisation.

Source: Ugeskrift for Læger

Authors: Shanga Hassan Qadir, Ruta Jakubauskaite, Emilie Lund Laursen

Institutions: Copenhagen University Hospital, Rigshospitalet

Language: English

Topic: Cancer Treatment and Pharmacology

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4412808934

FWCI:

Cites: 5

Cited by:

Related to: 10