Year: 2025
Type: article
Abstract: Thrombophilia can be defined as a predisposition to form clots inappropriately. The predisposition to form clots can arise from genetic factors, acquired changes in the clotting mechanism or, more commonly, through an interaction between genetic and acquired factors. Abnormalities in hemostasis that are associated with clinical thrombophilia include heritable defects, such as mutations in the genes encoding the natural anticoagulants antithrombin, protein C and protein S, or clotting factors prothrombin and factor V, and acquired defects, such as antiphospholipids. Women with thrombophilic defects have been shown to be at an increased risk not only of pregnancy associated thromboembolism, but also of other vascular complications of pregnancy, including preeclampsia and fetal loss.
Source: Ginecologia ro
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412809219