Work

Platelet-rich fibrin and concentrated growth factor in the treatment of immediate implants in teeth with periapical lesions: A clinical trial with two-year follow-up

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background. This study was designed to compare the effect of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on the immediate implants placed in previously infected sites. Methods. A total of 210 patients were included in this randomized clinical trial. The remaining tooth was extracted, and the periapical lesion was removed. Then, PRF and CGF were placed in the socket in the PRF and CGF groups, respectively. No intervention was performed in the control group. The implant was inserted and sutured. Postoperative pain was measured using VAS. Plaque index (PI), bleeding on probing (BOP), buccal and proximal gingival esthetic index (GEI-B and GEI-P), crestal bone level, periapical lesion size, and Implant Health Scale (IHS) were evaluated. Data were analyzed with SPSS 18 using one-way ANOVA, Tukey, and repeated measures test at 0.05 significance level. Results. The mean BOP and pain in each period were significantly higher in the control group than in the PRF and CGF groups and in the PRF group than in the CGF group (P=0.001 and P<0.001). In the PRF, CGF, and control groups, pain had a decreasing trend (P=0.010, P<0.001, and P=0.001); PI had a significant increasing trend (P=0.034, P<0.001, and P<0.001); crestal bone level had a significant increasing trend (P=0.023, P=0.033, and P<0.001); and the size of periapical lesion had a significant decreasing trend (P=0.004, P=0.002, and P=0.048). The IHS showed optimum health after two years in the PRF and CGF groups. Optimum health, satisfactory survival, and compromised survival were reported in the control group. Conclusion. PRF and CGF guaranteed the successful osseointegration of immediate implants in previously infected sites. CGF and PRF positively affected the soft tissue and hard tissue around the immediate implants. CGF had more promising effects than PRF.

Source: Journal of Dental Research Dental Clinics Dental Prospects

DOI: 10.34172/joddd.025.41670

Authors: Maryam Zohary, Meysam Malekzadeh, Ashkan Salari, Amin Afzali, Dina Maleki

Institutions: Guilan University of Medical Sciences, University of Guilan

Language: English

Topic: Dental Implant Techniques and Outcomes

Subfield: Oral Surgery

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412809406