Nickel Bioaccumulation in Oral Biofilm, Gingival Tissue, and Saliva During Fixed Orthodontic Treatment: A 12-Month Prospective Cohort Study on Predictors and Salivary pH Correlation
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Nickel-based alloys in fixed orthodontic appliances are susceptible to electrochemical corrosion in the oral environment, releasing ions with cytotoxic and allergenic potential. While previous studies have documented initial nickel release patterns, the longitudinal dynamics of its accumulation across oral biospaces (saliva, biofilm, gingival tissue) and interactions with salivary pH remain poorly characterized. This study investigates nickel accumulation in saliva, oral biofilm, and gingival tissue over 12 months of orthodontic treatment and its association with salivary pH. Material and Methods: This 12-month prospective cohort study enrolled 120 participants undergoing fixed orthodontic treatment. Nickel concentrations were quantified via graphite furnace atomic absorption spectrophotometry in three biospaces at baseline (T0), 6 months (T1), and 9-12 months (T2). Salivary pH was measured concurrently. Statistical analyses included non-parametric longitudinal comparisons, inter-biospace contrasts, Spearman correlations, and multivariate regression modeling to identify predictors of nickel accumulation. Results: =0.008), suggesting pH-microbiome interactions. Conclusions: Nickel, saliva, Spectrophotometry, Atomic, Orthodontic Appliances, Hydrogen-Ion Concentration.
DOI: 10.4317/jced.62923
Authors: L. Galviz-García, S. Romero-Romero, A. Herrera-Herrera, J. Mercado-Camargo, A. Díaz-Caballero, J. Plazas-Román, CM. Ardila
Language: English
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412816864