Transmembrane nanogold energy transfer ruler enables in situ synchronized projecting of receptor dimerization–phosphorylation signaling
Year: 2025
Type: article
Abstract: methods (poor spatiotemporal resolution), establishing a versatile framework for probing spatial regulation across diverse RTK signaling systems. Our results established the first quantitative paradigm for synchronously mapping phosphorylation dynamics and dimerization geometries with nanometer precision, offering unprecedented insights into allosteric transmembrane signaling mechanisms.
Source: Chemical Science
DOI: 10.1039/d5sc02717a
Authors: Xingru Fang, Xurui Cao, Xiaotong Zhang, Qi Li, Wenwen Huang, Yu Zhang, Honglin Liu
Institution: Hefei University of Technology
Language: English
Subfield: Biophysics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412823300