Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whole-exome and transcriptomic profiling.
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: This study aims to uncover the molecular biology and immune microenvironment of gynecological mesonephric-like adenocarcinoma (MLA). Methods: To determine the comprehensive characteristics of MLA, 17 patients with MLA were retrospectively enrolled in this study. Whole-exome sequencing and mRNA sequencing were performed to explore the molecular features. The biological differences between MLAs and epithelial-initiated gynecologic tumors reported in The Cancer Genome Atlas database were also analyzed. Results: MLAs, exhibited reduced immune infiltration in their tumor microenvironment. Conclusion: MLAs.
Source: PubMed
Authors: Jing Zeng, Qingli Li, Kemin Li, Lu Yang, Lian Xu, Wei Wang, Kaixuan Yang, Qingbo Wei, Jin Wang, Changbin Zhu, Rutie Yin
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412823335