Work

A novel biomaterial derived from the skin secretion of Andrias davidianus for dentinal tubule occlusion

Year: 2025

Type: article

Abstract: SSAD hydrolysate were evidently sealed by regenerated minerals. The deposited minerals were observed deep within the dentinal tubules (up to 30 ± 5 μm). X-Ray diffraction and energy-dispersive X-ray analyses further confirmed that the regenerated minerals were mainly hydroxyapatite. Sequentially, stable occlusion after acid challenge and significant reduction in dentin permeability were achieved. The microhardness value of the remineralized dentin treated with SSAD hydrolysate was significantly increased. In addition, the proliferation, migration, mineralization, and odontogenic differentiation of human dental pulp stem cells were promoted. Animal experiments indicated that SSAD hydrolysate could also occlude dentinal tubules in the oral environment. In conclusion, our work provides an experimental basis for the potential use of SSAD hydrolysate for treating dentin hypersensitivity.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d5tb00823a

Authors: Yongxiang Zeng, Lin Yang, Na Wu, Hong Chen, Ximu Zhang, Deqin Yang

Institutions: Stomatological Hospital of Chongqing Medical University, Chongqing Municipal Health Commission, Fudan University, Shanghai Stomatological Hospital

Language: English

Topic: Endodontics and Root Canal Treatments

Subfield: Oral Surgery

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, Chongqing Medical University, Natural Science Foundation of Chongqing, Chongqing Municipal Education Commission