Work

Hinge binder modification into imidazopyridine for targeting actionable mutations of RET kinase

Year: 2025

Type: article

Abstract: values as low as 11 nM against three distinct point mutations and three important RET fusions. The binding mode and measured potency were elucidated by induced-fit docking simulations and cardiotoxicity was evaluated.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00397k

Authors: Arunkranthi Maturi, Vinay Pogaku, Surendra Kumar, Mi-hyun Kim

Institution: Gachon University

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Gachon University, National Research Foundation of Korea

Awards: G1340347596, G7905840005

OpenAlex ID: W4412842160

FWCI: 0.608

Cites: 37

Cited by: 1

Related to: 10