Year: 2025
Type: article
Abstract: This review synthesizes insights from the studies investigating mechanisms and strategies for extending lifespan and healthspan. Telomere shortening is key to cellular aging, as evidenced by the fact that activation of telomerasein normal human cells prolongs their replicative lifespan by preserving telomere length and young cell phenotypes. Through the modulation of pathways such as sirtuins and caloric restriction mimetics, the polyphenolic molecule resveratrol improves agerelated illnesses and increases longevity and healthspan in model species. Nevertheless, there are difficulties in applying these advantages to people.Reactive oxygen species (ROS) produce cumulative oxidative damage to cellular macromolecules, including as proteins, lipids, and nucleic acids, which is closely associated with aging. An enzyme called peptide methionine sulfoxide reductase A (MSRA) fixes oxidized methionine residues in proteins. It has been linked to reducing oxidative damage and affecting longevity. With a primary focus on neural tissues, this study investigates the effects of MSRA overexpression in Drosophila melanogaster. The results show that transgenic flies that overexpress MSRA have noticeably longer lifespans, improved tolerance to oxidative stress caused by paraquat, and postponed reductions in physical and reproductive activity that are linked with senescence. MSRA's strong antioxidative mechanism is demonstrated by the lifespan extension attained with MSRA overexpression, which surpasses previous oxidative damage mitigation techniques.Finally, invertebrate models emphasize pharmacological methods to aging intervention, particularly high-throughput screening to uncover drugs that reduce aging.
Institution: Jawaharlal Nehru Technological University, Kakinada
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4412846381