A Comparison of the Levels of Serum Homocysteine and Their Relationship to Serum Vitamin B12 in Healthy Adults of Smokers and Non Smokers in Udaipur City
Year: 2024
Type: article
Study design: Observational Study
Abstract: Smoking is related to an increased risk of morbidity and mortality. Cigarette smoking has been related to higher levels of homocysteine in the blood. Both have been associated with a higher risk of cardiovascular disease. Smokers also have lower levels of vitamin B12, which affects homocysteine levels by serving as a cofactor or co substrate (folate) for the enzymes that regulate the metabolism of homocysteine. Objectives: The objective of this study is the comparison of the levels of homocysteine and their relationship to Vitamin B12 in healthy adults of Smokers and Non Smokers. Methodology: Total 300 patients were included in this study. The patients ranging within age 20-40 years, were further categorized according to use of tobacco smoking. Group A- This group consist of tobacco smoker patients between ages 20- 40 years. (n=150). Group B-This group consist of tobacco non-smoker patients between ages 20-40 years. (n=150). 10 ml blood was drawn through vein puncture. From all collected blood samples serum Vitamin B12 and Homocysteine levels measured. All collected data were analysed statistically to calculate p value to see the difference of significance. Results: The Mean concentration of S.homocysteine(µmol/L) in smoker group was 27.32±17.41 and 6.66±3.09 in control group and the difference among them found to be highly significant. Vitamin B12(pg/ml) was 288.7±108.6 in smokers & 459.8±165.7 in non smokers .Mean Vitamin B12 level is found lower in smokers as compared to non -smokers and it is found to be statistically significant (p<0.05). Conclusion: Based on the results, we came to the conclusion that smoking raises homocysteine levels and decreases vitamin B12 levels, which increases the risk of cardiovascular disease in long-term smokers.
DOI: 10.53555/sj7wga20
Author: Dr. Rashmi
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412849266