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Polygenic Risk Score Predicts IgA Nephropathy Recurrence and Graft Failure in Kidney Transplant Recipients

Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose: IgA nephropathy (IgAN) is a complex immune-mediated glomerular disease. A genome-wide polygenic risk score (GPS) for IgAN has been associated with native kidney IgAN and accelerated disease progression, but its role in post-kidney transplant (KTx) IgAN recurrence remains unclear.
DOI: 10.1016/j.ajt.2025.07.103
Authors: F. Zanoni, M. Naesens, R. Leal, Y. Caliskan, B. Keating, A. Gharavi, I. Batal, K. Kiryluk
Institutions: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, KU Leuven, Unidade Local de Saúde de Coimbra, Saint Louis University, New York University, Columbia University
Language: English
Subfield: Nephrology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412850410
FWCI:
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Related to: 10