Rapamycin during Normothermic Machine Perfusion Associated with Improved Function of Human Livers
Year: 2025
Type: article
Abstract: Purpose: Normothermic machine perfusion (NMP) of liver grafts allows for viability assessment and potential rehabilitation prior to transplantation. During NMP, recruitment of autophagy is associated with improved perfusion parameters and lactate clearance. To leverage the potential of this mechanism, we evaluated the effect of administering rapamycin, a known activator of autophagy, during NMP of non-utilized human livers.
Authors: A. Cutrone, C. Taveras, M. Mojoudi, O. Ozgur, M. Taggart, M. Hassan, A. Lyon, S. Raigani, K. Uygun, H. Yeh
Institutions: Massachusetts General Hospital, Duke Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412850445