Work

BMP-7 Mimetic (TBD 184) as a Prophylactic Agent Against Warm Ischemia in Perfused Rat Liver Grafts

Year: 2025

Type: article

Abstract: Purpose: Donation after cardiac death (DCD) livers are vulnerable to extended warm ischemic time (WIT), leading to primary non-function, delayed graft dysfunction, and ischemic cholangiopathy. These limitations reduce DCD graft viability. A potential strategy to enhance graft tolerance to warm ischemic (WI) damage is pharmacological intervention before withdrawal of life support. This study explores the prophylactic effects of BMP-7 mimetic (TBD 184), known for its anti-apoptotic, anti-fibrotic, anti-inflammatory, and pro-regenerative properties, using a normothermic machine perfusion (NMP) pump model.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.1887

Authors: A. Kharga, H. Chen, K. Uygun, J.F. Markmann, W.D. Carlson

Institutions: University of Pennsylvania Health System, University of Pennsylvania, Massachusetts General Hospital

Language: English

Topic: Organ Transplantation Techniques and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300