Work

Rapamycin during Normothermic Machine Perfusion: Exploring Response in a Rodent Model

Year: 2025

Type: article

Abstract: Purpose: We have observed that the function of discarded human livers during normothermic machine perfusion (NMP) correlates with autophagic flux and mTOR inhibition, and that adding mTOR inhibitors to the perfusate seems to improve liver function. Given the heterogeneity of discarded human livers, we developed a rat model to study autophagy and mTOR pathways, allowing for better control of relevant variables.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2025.07.1890

Authors: C. Taveras, A. Cutrone, E.O. Ajenu, S. Tessier, K. Uygun, H. Yeh

Institution: Massachusetts General Hospital

Language: English

Topic: Organ Transplantation Techniques and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300