Mitochondrial Injury and Function Comparing Hypothermic and Normothermic Machine Perfusion of Human Livers
Year: 2025
Type: article
Abstract: Purpose: Normothermic Machine Perfusion (NMP) is increasingly used for clinical liver transplantation in the US. In contrast, FDA-approval for hypothermic-oxygenated perfusion (HOPE) is currently awaited while in routine use in Europe. This study compares mitochondrial function and downstream reperfusion injury in human livers undergoing HOPE or NMP.
Authors: O. Karakaya, C. Jiao, K. Sun, S. Satish, B. Yoval-Sanchez, R. Panconesi, G. Crasta, F. Fernandes, S.F. Yildirim, L.A. Cadinu, C. Wehrle, R. Fairchild, C. Miller, K. Hashimoto, A. Galkin, A. Schlegel
Institutions: Cleveland Clinic, Cornell University, Weill Cornell Medicine
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4412850466